An international team of researchers, led by the universities of Bristol, UK, and Auckland, New Zealand, has finally uncovered the long-standing mystery of why many patients with high blood pressure (hypertension) also suffer from diabetes (high blood sugar). This significant discovery reveals that a small protein cell, glucagon-like peptide-1 (GLP-1), plays a crucial role in…
Scientists have pioneered a novel method for synthesizing peptides, potentially enhancing the efficiency and cost-effectiveness of drug manufacturing. Currently, over 70 peptide-based drugs are approved for clinical use, addressing conditions like diabetes, cancer, and HIV, with numerous others under development. As the demand for peptide treatments rises, advancements in peptide manufacturing technologies are crucial to…
Summary: Researchers have successfully reversed Alzheimer’s symptoms in mice using a synthetic peptide known as PHDP5. This peptide targets brain function by enhancing synaptic connectivity. Crucially, PHDP5 can cross the blood-brain barrier, significantly improving memory by restoring synaptic function. The study suggests that early administration of this treatment could delay cognitive decline, marking a significant…
A revolutionary study published in Nature unveils a new therapy for obesity that results in greater weight loss in mice compared to current treatments. This innovative method involves transporting molecules into the brain’s appetite center, impacting its neuroplasticity. “I consider the drugs available on the market today as the first generation of weight-loss drugs. Now…
Semaglutide, originally developed to treat type 2 diabetes and obesity, has shown significant improvements in symptoms for both men and women with a common, yet previously hard-to-treat type of heart failure. Presented by Dr. Subodh Verma at the American Diabetes Association’s 2024 Scientific Sessions and detailed in the Journal of the American College of Cardiology,…
Researchers from Baylor College of Medicine, along with their partners, have identified promising new targets for cancer therapy and gained new insights into existing cancer drugs. By integrating data from proteomics, genomics, and epigenomics across 10 types of cancer, the team pinpointed protein and peptide targets in cancer tissues. Many of these targets were validated…